Credit Text: 

Illustration by Lucy Reading-Ikkanda

Caption: 

The chromosome is represented snake-like, with the positions of "designer changes" indicated by pins and white diamonds, and the deleted segments indicated in yellow, using the native chromosome sequence as a reference. The approximate position of nucleosomes (protein "packaging" for the DNA in the chromosome) are indicated by the small dots in the center of the chromosome. The positions of the changes are roughly to scale.