Newcomb Cleveland Prize Recipients

2015 Recipient

The 2015 Newcomb Cleveland Prize was awarded to Bi-Chang Chen, Wesley R. Legant, Kai Wang, Lin Shao, Daniel E. Milkie, Michael W. Davidson, Chris Janetopoulos, Xufeng S. Wu, John A. Hammer III, Zhe Liu, Brian P. English, Yuko Mimori-Kiyosue, Daniel P. Romero, Alex T. Ritter, Jennifer Lippincott-Schwartz, Lillian Fritz-Laylin, R. Dyche Mullins, Diana M. Mitchell, Joshua N. Bembenek, Anne-Cecile Reymann, Ralph Böhme, Stephan W. Grill, Jennifer T. Wang, Geraldine Seydoux, U. Serdar Tulu, Daniel P. Kiehart, and Eric Betzig for their outstanding research article 'Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution'published in Science 24 October 2014. 

Animation defines life, and the three-dimensional (3D) imaging of dynamic biological processes occurring within living specimens is essential to understand life. However, in vivo imaging, especially in 3D, involves inevitable tradeoffs of resolution, speed, and phototoxicity. Chen et al. describe a microscope that can address these concerns. They used a class of nondiffracting beams, known as 2D optical lattices, which spread the excitation energy across the entire field of view while simultaneously eliminating out-of-focus excitation. Lattice light sheets increase the speed of image acquisition and reduce phototoxicity, which expands the range of biological problems that can be investigated. The authors illustrate the power of their approach using 20 distinct biological systems ranging from single-molecule binding kinetics to cell migration and division, immunology, and embryonic development. The authors created and successfully applied a fundamentally new method that can be utilized in various fields.

Past Recipients

Lulu Xie, Hogyi Kang,Qiwu Xu, Michael J. Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O’Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff ,Takahiro Takano, Rashid Deane, Maiken Nedergaard  for the report “Sleep Drives Metabolite Clearance from the Adult Brain” published in Science 18 October 2013, pp. 373-377.
Travis A. Jarrell, Yi Wang, Adam E. Bloniarz, Christopher A. Brittin, Meng Xu, J. Nichol Thomson, Donna G. Albertson, David H. Hall, and Scott W.Emmons  for the research article “The Connectome of a Decision-Making Neural Network,” published in Science 27 July, 2012 (pp. 437-444).
Vincent Mourik, Kun Zuo, Sergey M. Frolov, Sébastien R. Plissard, Erik P. A. M. Bakkers, and Leo P. Kouwenhoven  for the report “Signatures of Majorana Fermions in Hybrid Superconductor-Semiconductor Nanowire Devices” published in Science 25 May 2012, pp. 1003-1007.
Waseem S. Bakr, Amy Peng, M. Eric Tai, Ruichao Ma, Jonathan Simon, Jonathon Isaiah Gillen, Simon Fölling, Lode Pollet, and Markus Greiner for the research article “Probing the Superfluid-to-Mott Insulator Transition at the Single-Atom Level,” published in Science 30 July 2010, pp. 547-550.
Richard E. Green, Johannes Krause, Adrian W. Briggs, Tomislav Maricic, Udo Stenzel, Martin Kircher, Nick Patterson, Heng Li, Weiwei Zhai, Markus Hsi-Yang Fritz, Nancy F. Hansen, Eric Y. Durand, Anna-Sapfo Malaspinas, Jeffrey D. Jensen, Tomas Marques-Bonet, Can Alkan, Kay Prüfer, Matthias Meyer, Hernán A. Burbano, Jeffrey M. Good, Rigo Schultz, Ayinuer Aximu-Petri, Anne Butthof, Barbara Höber, Barbara Höffner, Madlen Siegemund, Antje Weihmann, Chad Nusbaum, Eric S. Lander, Carsten Russ, Nathaniel Novod, Jason Affourtit, Michael Egholm, Christine Verna, Pavao Rudan, Dejana Brajkovic, Željko Kucan, Ivan Gušic, Vladimir B. Doronichev, Liubov V. Golovanova, Carles Lalueza-Fox, Marco de la Rasilla, Javier Fortea, Antonio Rosas, Ralf W. Schmitz, Philip L. F. Johnson, Evan E. Eichler, Daniel Falush, Ewan Birney, James C. Mullikin, Montgomery Slatkin, Rasmus Nielsen, Janet Kelso, Michael Lachmann, David Reich, and Svante Pääbo for the research article “A Draft Sequence of the Neandertal Genome,” published in Science 7 May 2010, pp. 653-776.
Paul Kalas, James R. Graham, Eugene Chiang, Michael P. Fitzgerald, Mark Clampin, Edwin S. Kite, Karl Stapelfeldt, Christian Marois, and John Krist for the research article “Optical Images of an Exosolar Planet 25 Light-Years from Earth,” published in Science 28 November 2008, pp. 1345-1348
Christian Marois, Bruce Macintosh, Travis Barman, B. Zuckerman, Inseok Song, Jennifer Patience, David Lafrenière, and René Doyon for the research article “Direct Imaging of Multiple Planets Orbiting the Star HR 8799,” published in Science 28 November 2008, pp. 1348-1352.
Anoop Kumar, James W. Godwin, Phillip B. Gates, A. Acely Garza-Garcia, and Jeremy P. Brockesfor the research article “Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate,” published in Science 2 November 2007, pp. 772-777.
Hani M. El-Kaderi, Joseph R. Hunt, José L. Mendoza-Cortés, Adrien P. Côté, Robert E. Taylor, Michael O’Keeffe, and Omar M. Yaghi for the report “Designed Synthesis of 3D Covalent Organic Frameworks,” published in Science on 13 April 2007, pp. 268—272.
Jason R. Petta, Alexander C. Johnson, Jacob M. Taylor, Edward A. Laird, Amir Yacoby, Mikhail D. Lukin, Charles M. Marcus, Micah P. Hanson, Arthur C. Gossard for the research article “Coherent Manipulation of Coupled Electron Spins in Semiconductor Quantum Dots,” published online inScience Express 1 September 2005, published in print 30 September 2005, pp. 2180-2184.
David D. Awschalom, Yuichiro K. Kato, Roberto C. Myers, and Arthur C. Gossard for the research article “Observation of the Spin Hall Effect in Semiconductors,” published in Science, 10 December 2004, pp. 1910-1913. At the time of publication, the authors’ affiliation was the Center for Spintronics and Quantum Computation, University of California, Santa Barbara. Currently, Kato is at Stanford University.
Brian Kuhlman, Gautam Dantas, Gregory C. Ireton, Gabriele Varani, Barry L. Stoddard and David Baker for “Design of a Novel Globular Protein Fold with Atomic-Level Accuracy,” published inScience 21 November 2003.
Thomas A. Volpe, Catherine Kidner, Ira M. Hall, Grace Teng, Shiv I.S. Grewal and Robert A. Martienssen for the research article “Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi,” published in Science, 13 September 2002, pp. 1833-1837and
Ira M. Hall, Gurumurthy D. Shankaranarayana, Ken-ichi Noma, Nabieh Ayoub, Amikam Cohen and Shiv I.S. Grewal for the research article “Establishment and Maintenance of a Heterochromatin Domain,” published in Science, 27 September 2002, pp. 2232-2236
Mariana Lagos-Quintana, Reinhard Rauhut, Winfried Lendeckel, and Thomas Tuschl for the report “Identification of Novel Genes Coding for Small Expressed RNAs,” published in Science, 26 October 2001;
Nelson C. Lau, Lee P. Lim, Earl G. Weinstein, and David P. Bartel for the report “An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans,” published in Science, 26 October 2001;and
Rosalind C. Lee and Victor Ambros for the report, “An Extensive Class of Small RNAs inCaenorhabditis elegans,” published in Science, 26 October 2001.
Nenad Ban, Poul Nissen, Jeffrey Hansen, Peter B. Moore, and Thomas A. Steitz for the research article “The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution,” published in Science, 11 August 2000;
Poul Nissen, Jeffrey Hansen, Nenad Ban, Peter B. Moore, and Thomas A. Steitz for the research article “The Structural Basis for Ribosome Activity in Peptide Bond Synthesis,” published in Science, 11 August 2000;and
Marat M. Yusupov, Gulnara Gh. Yusupova, Albion Baucom, Kate Lieberman, Thomas N. Earnest, J.H.D. Cate, and Harry F. Noller for the research article “Crystal Structure of the Ribosome at 5.5 Å Resolution,” published in Science, 4 May 2001.
Mark D. Adams, Susan E. Celniker, Gerald M. Rubin and J. Craig Venter for the review “The Genome Sequence of Drosophilia melanogaster,” 24 March 2000.
Norman Murray and Matthew Holman for the research article “The Origin of Chaos in the Outer Solar System,” 19 March 1999.
Declan A. Doyle, João Morais Cabral, Richard A. Pfuetzner, Anling Kuo, Jacqueline M. Gulbis, Steven L. Cohen, Brian T. Chait and Roderick MacKinnon for the research article “The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity,” 3 April, 1998;and
Roderick MacKinnon, Steven L. Cohen, Anling Kuo, Alice Lee and Brian T. Chait for the report “Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels,” 3 April 1998.
Nicholas C. Wrighton, Francis X. Farrell, Ray Chang, Arun K. Kashyap, Francis Barbone, Linda S. Mulcahy, Dana L. Johnson, Ronald W. Barrett, Linda K. Jolliffe and William J. Dower for the research article “Small peptides as Potent Mimetics of the Protein Hormone Erythropoietin,” 26 July 1996;and
Oded Livnah, Enrico A. Stura, Dana L. Johnson, Steven A. Middleton, Linda S. Mulcahy, Nicholas C. Wrighton, William J. Dower, Linda K. Jolliffe and Ian A. Wilson for the research article “Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO receptor Complex at 2.8 Å,” 26 July 1996.

For a complete listing of past Newcomb Cleveland Prize recipients, please see the AAAS Archives.

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