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Center for Public Engagement with Science and Technology

Triple-A S: Advancing Science, Serving Society

AAAS Centers: Center for Public Engagement with Science and Technology

http://www.aaas.org//programs/centers/pe/abelson/abelson.shtml


Philip Hauge Abelson

Philip Hauge Abelson

Philip Hauge Abelson Advancing Science Seminar Series

Science editor emeritus Dr. Philip Hauge Abelson was one of the most extraordinary scientists of our age. The quality and range of his work was astounding. He made major contributions to physics, geology, geochemistry, geophysics, and molecular biology. His positions of leadership and service on national advisory committees enabled him to shape national science and technology policy. And under his 22-year tenure as the editor-in-chief of Science, he took the journal to a new level of quality and prominence.

One of the most remarkable aspects of Dr. Abelson’s role as AAAS senior adviser and Science editor emeritus was that his interests focused on the cutting edge and the future, not the past. He founded and sponsored “The Advancing Science Seminar Series” to encourage participants to think about where science is going, not where it has been. The series has since been renamed in his honor.

This year’s Advancing Science Seminar—“Breaching Barriers in Alzheimer’s Disease”—appropriately reflects Dr. Abelson’s enthusiasm for pushing scientific boundaries and leveraging science to improve human quality-of-life. This year’s event will emphasize cross-disciplinary information-sharing among researchers to speed the development of new treatments for Alzheimer’s disease, in keeping with the goals of Science Translational Medicine, the latest journal published by AAAS. A daylong public symposium will focus on understanding the genetic and molecular factors that underlie Alzheimer’s disease, the use of imaging and biomarkers to detect the disease in its earliest stages, and new strategies for developing effective therapeutics.


Breaching Barriers in Alzheimer’s Disease

[PHOTOGRAPH] A silver stain image of the signature pathological lesions in the Alzheimer's disease brain: an amyloid plaque (left) and a neurofibrillary tangle (right). [Photo courtesy of Nigel Cairns, Washington University]]

A silver stain image of the signature pathological lesions in the Alzheimer's disease brain: an amyloid plaque (left) and a neurofibrillary tangle (right).

[Photo courtesy of Nigel Cairns, Washington University]

Wednesday 6 April 2011

Alzheimer’s disease (AD) affects an estimated 4 to 5 million Americans, who progress from minor memory problems and behavior changes, to complete incapacity and loss of self, to death. As the Baby Boomer generation ages, it is estimated that the number of Americans with the disease will reach much higher. Although a handful of drugs can relieve symptoms, no treatments are available to safely halt or slow the disease. However, AD-related research is revealing the genetic and molecular factors that underlie the disease, the importance of neuroimaging and biomarkers to detect AD in its earliest stages, and new treatment strategies, including the development of vaccines and small molecule drugs. Research from the front lines of our efforts to combat Alzheimer’s disease will be explored during the 2011 Philip Hauge Abelson Advancing Science Seminar.

Watch the Abelson Seminar

Watch all of the speakers in the “Breaching Barriers in Alzheimer’s Disease” event.

Morning Session
[PHOTOGRAPH] Alan I. Leshner [Photos by Michael Colella, Colellaphoto.com]

Alan I. Leshner

Chief Executive Officer, AAAS, and Executive Publisher of the journal Science

Welcome

8:30 a.m.—8:40 a.m.

[PHOTOGRAPH] John Abelson

John Abelson

President and Executive Director, The Agouron Institute

8:40 a.m.—9:00 a.m.

Session I: Glimpses Into the Alzheimer’s Brain
[PHOTOGRAPH] David M. Holtzman

David M. Holtzman

Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Washington University School of Medicine

Overview of Alzheimer’s Disease: Why We Need Biomarkers

9:00 a.m.—9:30 a.m.

[PHOTOGRAPH] Mark A. Mintun

Mark A. Mintun

Chief Medical Officer, Avid Radiopharmaceuticals

Imaging Molecules and Pathways in Alzheimer’s Disease

9:30 a.m.—10:00 a.m.

[PHOTOGRAPH] Alison Goate

Alison Goate

Samuel and Mae S. Ludwig Professor of Genetics in Psychiatry, Washington University School of Medicine

New Insights into the Genetics of Late-Onset Alzheimer's Disease

10:15 a.m.—10:45 a.m.

[PHOTOGRAPH] Dennis J. Selkoe

Dennis J. Selkoe

Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School

The Molecular Complexity of Alzheimer’s Disease

10:45 a.m.—11:15 a.m.

[PHOTOGRAPH] Reisa Sperling

Reisa Sperling

Associate Professor of Neurology, Harvard Medical School
Director, Center for Alzheimer Research and Treatment
Brigham and Women's Hospital
Massachusetts General Hospital

Can We Detect and Treat Alzheimer's Disease a Decade Prior to Dementia (and Why Would We Want to)?

11:15 a.m.—11:45 a.m.

Watch Sperling’s answer regarding behavioral interventions for alzheimer’s patients
[PHOTOGRAPH] David M. Holtzman, Mark A. Mintun, Alison Goate, Dennis J. Selkoe, and Steven M. Paul

Questions & Answers

David M. Holtzman, Mark A. Mintun, Alison Goate, Dennis J. Selkoe, and Reisa Sperling

11:45 a.m.—Noon

Session II: Aberrant Cells And Proteins In Neurodegenerative Disease
[PHOTOGRAPH] Marc Tessier-Lavigne

Marc Tessier-Lavigne

President, The Rockefeller University

Session Chair

[PHOTOGRAPH] Jeffrey W. Kelly

Jeffrey W. Kelly

Lita Annenberg Hazen Professor of Chemistry, Scripps Research Institute

Restoring Protein Homeostasis in Neurodegenerative Disease

1:00 p.m.—1:30 p.m.

[PHOTOGRAPH] Mathias Jucker

Mathias Jucker

Director, Hertie Institute for Clinical Brain Research, University of Tübingen

Propagation of Misfolded Proteins in the Brain

1:30 p.m.—2:00 p.m.

[PHOTOGRAPH] Richard Morimoto

Richard Morimoto

John Evans Professor of Biology, Northwestern University

Stress Responses and Chaperone Networks in Neurodegenerative Disease

2:00 p.m.—2:30 p.m.

Session II Continued: Aberrant Cells And Proteins In Neurodegenerative Disease
[PHOTOGRAPH] Li-Huei Tsai

Li-Huei Tsai

Director, Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Session Chair

[PHOTOGRAPH] Steven Finkbeiner

Steven Finkbeiner

Senior Investigator and Associate Director, Gladstone Institute of Neurological Disease

Can Common Threads Guide Therapeutic Development in Huntington's and Alzheimer's disease?

3:00 p.m.—3:30 p.m.

[PHOTOGRAPH] Don W. Cleveland

Don W. Cleveland

Professor of Medicine, Neurosciences, and Cellular and Molecular Medicine, University of California at San Diego

Neurodegenerative Disease: More Than Just the Neurons

3:30 p.m.—4:00 p.m.

[PHOTOGRAPH] Serge Przedborski

Serge Przedborski

Page and William Black Professor of Neurology, Columbia University

Cell Death Cascades in Neurodegeneration

4:00 p.m.—4:30 p.m.

[PHOTOGRAPH] Richard Ransohoff

Richard Ransohoff

Director, Neuroinflammation Research Center, Cleveland Clinic

Neuroinflammation’s Tipping Point: Myeloid Cells in Alzheimer’s Disease

4:30 p.m.—5:00 p.m.

[PHOTOGRAPH] Andrew Dillin

Andrew Dillin

Associate Professor, Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies

Targeting Aging, the Greatest Risk Factor for Alzheimer’s Disease

5:00 p.m.—5:30 p.m.

Sponsors

This seminar was made possible by the following:

The Agouron Institute [Image © The Agouron Institute] Science Translational Medicine / Triple-A-S Triple-A-S

The Abelson Advancing Science Seminar Series Advisory Committee

AAAS thanks the Abelson Advancing Science Seminar Series Advisory Committee. Members include colleagues and family members of Dr. Abelson who help to preserve his vision.

John Abelson

Ellen Abelson Cherniavsky

Mr. and Mrs. John P. Cherniavsky

Neva Cherniavsky

Stephen P.A. Fodor

Maxine Frank Singer

Past Abelson Advancing Science Seminars

Translational Medicine & Human Health” [20 November 2009]

Science, Stress, and Human Health” [24 October 2008]

New Horizons in Polar Science” [30 October 2007]

Microbes, Minerals, and the Environment” [26 October 2006]

New Directions in Health:” The Global Burden of Chronic Disease [8 December 2005]

 
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