Chief Executive Officer, AAAS, and Executive Publisher of the journal Science
8:30 a.m.—8:40 a.m.
Philip Hauge Abelson
Science editor emeritus Dr. Philip Hauge Abelson was one of the most extraordinary scientists of our age. The quality and range of his work was astounding. He made major contributions to physics, geology, geochemistry, geophysics, and molecular biology. His positions of leadership and service on national advisory committees enabled him to shape national science and technology policy. And under his 22-year tenure as the editor-in-chief of Science, he took the journal to a new level of quality and prominence.
One of the most remarkable aspects of Dr. Abelson’s role as AAAS senior adviser and Science editor emeritus was that his interests focused on the cutting edge and the future, not the past. He founded and sponsored “The Advancing Science Seminar Series” to encourage participants to think about where science is going, not where it has been. The series has since been renamed in his honor.
This year’s Advancing Science Seminar—“Breaching Barriers in Alzheimer’s Disease”—appropriately reflects Dr. Abelson’s enthusiasm for pushing scientific boundaries and leveraging science to improve human quality-of-life. This year’s event will emphasize cross-disciplinary information-sharing among researchers to speed the development of new treatments for Alzheimer’s disease, in keeping with the goals of Science Translational Medicine, the latest journal published by AAAS. A daylong public symposium will focus on understanding the genetic and molecular factors that underlie Alzheimer’s disease, the use of imaging and biomarkers to detect the disease in its earliest stages, and new strategies for developing effective therapeutics.
A silver stain image of the signature pathological lesions in the Alzheimer's disease brain: an amyloid plaque (left) and a neurofibrillary tangle (right).
[Photo courtesy of Nigel Cairns, Washington University]
Wednesday 6 April 2011
Alzheimer’s disease (AD) affects an estimated 4 to 5 million Americans, who progress from minor memory problems and behavior changes, to complete incapacity and loss of self, to death. As the Baby Boomer generation ages, it is estimated that the number of Americans with the disease will reach much higher. Although a handful of drugs can relieve symptoms, no treatments are available to safely halt or slow the disease. However, AD-related research is revealing the genetic and molecular factors that underlie the disease, the importance of neuroimaging and biomarkers to detect AD in its earliest stages, and new treatment strategies, including the development of vaccines and small molecule drugs. Research from the front lines of our efforts to combat Alzheimer’s disease will be explored during the 2011 Philip Hauge Abelson Advancing Science Seminar.
Watch all of the speakers in the “Breaching Barriers in Alzheimer’s Disease” event.
President and Executive Director, The Agouron Institute
8:40 a.m.—9:00 a.m.
David M. Holtzman
Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Washington University School of Medicine
Overview of Alzheimer’s Disease: Why We Need Biomarkers
9:00 a.m.—9:30 a.m.
Mark A. Mintun
Chief Medical Officer, Avid Radiopharmaceuticals
Imaging Molecules and Pathways in Alzheimer’s Disease
9:30 a.m.—10:00 a.m.
Samuel and Mae S. Ludwig Professor of Genetics in Psychiatry, Washington University School of Medicine
New Insights into the Genetics of Late-Onset Alzheimer's Disease
10:15 a.m.—10:45 a.m.
Dennis J. Selkoe
Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School
The Molecular Complexity of Alzheimer’s Disease
10:45 a.m.—11:15 a.m.
Associate Professor of Neurology, Harvard Medical School
Director, Center for Alzheimer Research and Treatment
Brigham and Women's Hospital
Massachusetts General Hospital
Can We Detect and Treat Alzheimer's Disease a Decade Prior to Dementia (and Why Would We Want to)?
11:15 a.m.—11:45 a.m.
Questions & Answers
David M. Holtzman, Mark A. Mintun, Alison Goate, Dennis J. Selkoe, and Reisa Sperling
President, The Rockefeller University
Jeffrey W. Kelly
Lita Annenberg Hazen Professor of Chemistry, Scripps Research Institute
Restoring Protein Homeostasis in Neurodegenerative Disease
1:00 p.m.—1:30 p.m.
Director, Hertie Institute for Clinical Brain Research, University of Tübingen
Propagation of Misfolded Proteins in the Brain
1:30 p.m.—2:00 p.m.
John Evans Professor of Biology, Northwestern University
Stress Responses and Chaperone Networks in Neurodegenerative Disease
2:00 p.m.—2:30 p.m.
Director, Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Senior Investigator and Associate Director, Gladstone Institute of Neurological Disease
Can Common Threads Guide Therapeutic Development in Huntington's and Alzheimer's disease?
3:00 p.m.—3:30 p.m.
Don W. Cleveland
Professor of Medicine, Neurosciences, and Cellular and Molecular Medicine, University of California at San Diego
Neurodegenerative Disease: More Than Just the Neurons
3:30 p.m.—4:00 p.m.
Page and William Black Professor of Neurology, Columbia University
Cell Death Cascades in Neurodegeneration
4:00 p.m.—4:30 p.m.
Director, Neuroinflammation Research Center, Cleveland Clinic
Neuroinflammation’s Tipping Point: Myeloid Cells in Alzheimer’s Disease
4:30 p.m.—5:00 p.m.
Associate Professor, Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies
Targeting Aging, the Greatest Risk Factor for Alzheimer’s Disease
5:00 p.m.—5:30 p.m.
This seminar was made possible by the following:
AAAS thanks the Abelson Advancing Science Seminar Series Advisory Committee. Members include colleagues and family members of Dr. Abelson who help to preserve his vision.
Ellen Abelson Cherniavsky
Mr. and Mrs. John P. Cherniavsky
Stephen P.A. Fodor
Maxine Frank Singer
“Translational Medicine & Human Health” [20 November 2009]
“Science, Stress, and Human Health” [24 October 2008]
“New Horizons in Polar Science” [30 October 2007]
“Microbes, Minerals, and the Environment” [26 October 2006]
“New Directions in Health:” The Global Burden of Chronic Disease [8 December 2005]