Aging is associated with a continuous decrease in optimal mitochondrial respiratory activity i.e., mitochondrial dysfunction. This process is speculated to be responsible for reduced ATP production, which is essential for tissue homeostasis and stress response. It may also lead to elevation in oxidative stress, which could cause damage to proteins, lipids, and DNA, thus triggering tissue degeneration and cancer during aging. Yet, antioxidants have failed to improve healthspan.
Research in worms, flies, and mice indicates that minor increments in oxidative stress or decreased respiratory function could induce adaptive responses, providing a protective effect during aging. Further complicating this picture are observations that interventions like exercise, caloric restriction, and supplements like NAD+ boosters or taurine improve healthspan with a correlation in increasing mitochondrial respiratory function. An important unresolved issue is identifying the tissues where respiratory function becomes the limiting factor for healthspan. In this webinar, we will discuss whether modest increase or decrease in mitochondrial respiratory function is adaptive or detrimental for healthspan.
Who should attend:
The webinar is designed for researchers, pharmaceutical professionals, and the general public.