Thanks for the Memory B Cells. This image shows the fusion glycoprotein of respiratory syncytial virus (RSV). Infection with RSV can cause severe disease in infants and older adults, making an RSV vaccine essential for protecting these populations. Here, Phung et al. characterized the memory B cell response elicited by an RSV prefusion (pre-F)-stabilized glycoprotein vaccine candidate, DS-Cav1. One or two doses of DS-Cav1 generated pre-F–specific memory B cell responses that cross-reacted against human metapneumovirus (HMPV) pre-F glycoprotein. These results indicate that DS-Cav1 may confer protection against both RSV and HMPV, supporting its further clinical development.
Credit: Laguna Design/Science Source