Reversing Glomerulonephritis. The cover image shows a 3D reconstruction of a whole glomerulus using optical tissue clearing of kidney sections from a mouse with crescentic glomerulonephritis treated with the drug panobinostat. Administration of panobinostat, which is used to treat hematopoietic stem cell disorders, reduced the formation of pathological crescents in the kidneys of mice with severe glomerulonephritis. Panobinostat treatment increased podocyte production by boosting differentiation of renal epithelial progenitor cells (Melica et al.). The increase in podocytes, revealed by staining for the podocyte marker podocin (expression of which is indicated by staining density), led to decreased proteinuria and improved kidney function in these animals, suggesting the potential of panobinostat for treating human glomerulonephritis.
Credit: Melica et al./Science Translational Medicine