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Science Celebrates Cancer Immunotherapy and More in Annual Top 10 List


Antibodies (pink) zoom toward a T cell (gray, with CTLA-4 receptor proteins shown in light blue), giving the T cell a push to attack tumor cells. In 2013, new therapies targeting the immune system to treat cancer surged ahead, with promising but still preliminary results in people with many forms of the disease. Valerie Altounian/Science

The cancer research community experienced a sea change in 2013 as a treatment strategy, decades in the making, finally cemented its potential. Promising results emerged from clinical trials of cancer immunotherapy, which targets the body's immune system rather than tumors directly. The new treatments push T cells and other immune cells to combat cancer — and the editors of Science believe that such approaches are now displaying enough promise to top their list of the year's most important scientific breakthroughs.

This annual list of groundbreaking scientific achievements selected by Science also includes major breakthroughs in solar cell technologies, genome-editing techniques and vaccine design strategies. The top 10 list appears in the 20 December issue of the journal.

Cancer immunotherapy clinched the number-one spot on the list because, although its ultimate impact on the disease is unknown, recent results are highlighting its success so far.

"This year there was no mistaking the immense promise of cancer immunotherapy," said Tim Appenzeller, chief news editor of Science. "So far, this strategy of harnessing the immune system to attack tumors works only for some cancers and a few patients, so it's important not to overstate the immediate benefits. But many cancer specialists are convinced that they are seeing the birth of an important new paradigm for cancer treatment."

Many of today's advances in cancer immunotherapy can be traced back to the late 1980s, when French researchers identified a receptor on T cells, called CTLA-4. James Allison, now at the University of Texas MD Anderson Cancer Center in Houston, discovered that this receptor prevented T cells from attacking invaders with their full force. In the mid-1990s Allison showed that blocking CTLA-4 in mice could unleash T cells against tumor cells in the animals, shrinking them dramatically.

In the meantime, Japanese researchers identified another "brake" on T cells known as PD-1. Clinical trials involving this receptor began in 2006, and preliminary results in small groups of patients appear to be promising.

Another area of interest involves genetically modifying T cells to make them target tumors. In 2011 this strategy, known as chimeric antigen therapy, or CAR therapy, electrified the cancer research field, and it's now the subject of numerous clinical trials, particularly in blood cancers.

Accordingly, many pharmaceutical companies that wanted nothing to do with immunotherapy several years ago are now investing heavily.

There's still lots of uncertainty regarding how many patients will benefit from these therapies — most of which remain experimental — and for which forms of cancer they will work best. Scientists are busy trying to identify biomarkers that might offer answers, and thinking of ways to make treatments more potent. But a new chapter in cancer research and treatment has begun and the journal Science acknowledges this fact by recognizing cancer immunotherapy as the most significant scientific breakthrough of 2013.

Each December, the editors of Science reflect back upon the major scientific discoveries of the year and choose one which they believe to be the most significant. This animation from the AAAS Office of Public Programs features this groundbreaking achievement, as well as nine runners-up that made big waves in 2013. Science/AAAS

The journal's list of nine other groundbreaking scientific achievements from the past year follows:

CRISPR: This gene-editing technique was discovered in bacteria, but researchers now wield it as a scalpel for surgery on individual genes. Its popularity soared this year as more than a dozen teams of researchers used it to manipulate the genomes of various plant, animal and human cells.

Perovskite Solar Cells: A new generation of solar-cell materials, cheaper and easier to produce than those in traditional silicon cells, garnered plenty of attention this past year. Perovskite cells are not as efficient as commercial solar cells yet, but they are improving very quickly.

Structural Biology Guides Vaccine Design: This year, researchers used the structure of an antibody to design an immunogen — the main ingredient of a vaccine — for a childhood virus called respiratory syncytial virus that hospitalizes millions each year. It was the first time that structural biology led to such a powerful tool for fighting disease.

CLARITY: This imaging technique, which renders brain tissue transparent and puts neurons (as well as other brain cells) on full display, changed the way that researchers look at this intricate organ in 2013.

Watch Science News video coverage of this year's breakthrough and runners-up, as well as a behind-the-scenes look at the Science editorial team's selection process.

Mini-Organs: Researchers made remarkable progress growing mini, human-like "organoids" in vitro this year. These included liver buds, mini-kidneys and tiny brains. Such miniaturized human organs may prove to be much better models of human disease than animals.

Cosmic Rays Traced to Supernova Remnants: Although they originally detected cosmic rays 100 years ago, scientists haven't been sure where the high-energy particles come from in outer space. This year, they finally tied the rays to debris clouds left by supernovae, or exploding stars.

Human Cloned Embryos: Researchers were able to derive stem cells from cloned human embryos this year after realizing that caffeine plays an important role in the process, stabilizing key molecules in delicate, human egg cells.

Why We Sleep: Studies with mice showed that the brain cleans itself — by expanding channels between neurons and allowing more cerebrospinal fluid to flow through — much more efficiently during sleep. The finding suggests that restoration and repair are among the primary purposes of catching Zs.

Our Microbes, Our Health: Research on the trillions of bacterial cells that call the human body home made it clear how much these microbes do for us. "Personalized" medicine will need to take these microbial tenants into account in order to be effective.